Compound Detail
CHEMBL392524
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL392524 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BKZNLTGYHSYTIZ-YRJIXQRISA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
364.5
MW (Da)
4.02
ALogP
2
HBA
1
HBD
46.3
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 7.92 | 7.165 | 12.0 | 2 |
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 5.51 | 5.51 | 3100.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 5.44 | 5.44 | 3600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of human DPP4 | 17851076 |
| Dipeptidyl peptidase 4 | IC50 | = | 390.0 | nM | 6.41 | Inhibition of human DPP4 in presence of 50 % human serum | 17851076 |
| Dipeptidyl peptidase 9 | IC50 | = | 3100.0 | nM | 5.51 | Inhibition of human DPP9 | 17851076 |
| Dipeptidyl peptidase 8 | IC50 | = | 3600.0 | nM | 5.44 | Inhibition of human DPP8 | 17851076 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17851076 | 10.1016/j.bmcl.2007.08.049 | Dipeptidyl peptidase 4 | 2 |
| 17851076 | 10.1016/j.bmcl.2007.08.049 | Dipeptidyl peptidase 8 | 1 |
| 17851076 | 10.1016/j.bmcl.2007.08.049 | Dipeptidyl peptidase 9 | 1 |
Data from ChEMBL 36 via Core Engine