Assay Detail
Binding
CHEMBL898850
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Inhibition of human DPP4
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.63 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237152 | — | — | 1 | 8.82 |
| CHEMBL400841 | — | — | 1 | 8.64 |
| CHEMBL237997 | — | — | 1 | 8.60 |
| CHEMBL237337 | — | — | 1 | 8.40 |
| CHEMBL237151 | — | — | 1 | 8.34 |
| CHEMBL437557 | — | — | 1 | 8.32 |
| CHEMBL238190 | — | — | 1 | 7.96 |
| CHEMBL237119 | — | — | 1 | 7.92 |
| CHEMBL392524 | — | — | 1 | 7.92 |
| CHEMBL237547 | — | — | 1 | 7.80 |
| CHEMBL238191 | — | — | 1 | 7.50 |
| CHEMBL235199 | — | — | 1 | 7.42 |
| CHEMBL237336 | — | — | 1 | 7.19 |
| CHEMBL235004 | — | — | 1 | 7.00 |
| CHEMBL237972 | — | — | 1 | 6.82 |
| CHEMBL235198 | — | — | 1 | 6.66 |
| CHEMBL237783 | — | — | 1 | 6.58 |
| CHEMBL235223 | — | — | 1 | 6.58 |
| CHEMBL237566 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237152 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL400841 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL237997 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL237337 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL237151 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL437557 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL238190 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL237119 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL392524 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL237547 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL238191 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL235199 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL237336 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL235004 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL237972 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL235198 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL237783 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL235223 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL237566 | — | IC50 | = | 310.0 | nM | 6.51 |