Assay Detail
Binding
CHEMBL898896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AVP from human vasopressin V2 receptor expressed in mouse LV2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LV2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.31 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49429 | LIXIVAPTAN | 3.0 | 1 | 8.92 |
| CHEMBL363910 | — | — | 1 | 7.09 |
| CHEMBL237120 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49429 | LIXIVAPTAN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL363910 | — | IC50 | = | 80.3 | nM | 7.09 |
| CHEMBL237120 | — | IC50 | = | 1214.0 | nM | 5.92 |