Assay Detail
Functional
CHEMBL899067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on acid secretion in rabbit intact gastric glands assessed as inhibition of [14C]dimethylaminopyridine accumulation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Gastric gland |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.71 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296482 | — | — | 1 | 7.20 |
| CHEMBL392544 | — | — | 1 | 6.50 |
| CHEMBL241801 | — | — | 1 | 6.40 |
| CHEMBL442250 | — | — | 1 | 6.10 |
| CHEMBL391485 | — | — | 1 | 6.00 |
| CHEMBL238822 | — | — | 1 | 5.90 |
| CHEMBL239034 | — | — | 1 | 5.70 |
| CHEMBL391200 | — | — | 1 | 5.70 |
| CHEMBL392749 | — | — | 1 | 5.20 |
| CHEMBL240099 | — | — | 1 | 5.10 |
| CHEMBL238839 | — | — | 1 | 5.10 |
| CHEMBL240337 | — | — | 1 | 5.00 |
| CHEMBL400204 | — | — | 1 | 5.00 |
| CHEMBL392543 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296482 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL392544 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL241801 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL442250 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL391485 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL238822 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL239034 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL391200 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL392749 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL240099 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL238839 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL240337 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL400204 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL392543 | — | IC50 | = | 10000.0 | nM | 5.00 |