Assay Detail
Binding
CHEMBL899128
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Inhibition of human serum AChE by Ellman colorimetric assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.81 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | 2.0 | 1 | 7.35 |
| CHEMBL392324 | — | — | 1 | 7.16 |
| CHEMBL332051 | — | — | 1 | 7.08 |
| CHEMBL398406 | — | — | 1 | 7.08 |
| CHEMBL240792 | — | — | 1 | 6.87 |
| CHEMBL240793 | — | — | 1 | 6.64 |
| CHEMBL241011 | — | — | 1 | 6.63 |
| CHEMBL325502 | — | — | 1 | 6.62 |
| CHEMBL115835 | — | — | 1 | 6.57 |
| CHEMBL415675 | — | — | 1 | 6.54 |
| CHEMBL397891 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54126 | NEOSTIGMINE BROMIDE | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL392324 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL332051 | — | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL398406 | — | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL240792 | — | IC50 | = | 135.4 | nM | 6.87 |
| CHEMBL240793 | — | IC50 | = | 230.8 | nM | 6.64 |
| CHEMBL241011 | — | IC50 | = | 231.5 | nM | 6.63 |
| CHEMBL325502 | — | IC50 | = | 240.6 | nM | 6.62 |
| CHEMBL115835 | — | IC50 | = | 268.8 | nM | 6.57 |
| CHEMBL415675 | — | IC50 | = | 286.4 | nM | 6.54 |
| CHEMBL397891 | — | IC50 | = | 383.5 | nM | 6.42 |