Assay Detail
Binding
CHEMBL899137
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Inhibition of human recombinant caspase 3 by fluorometric assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.44 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237310 | — | — | 1 | 7.48 |
| CHEMBL237308 | — | — | 1 | 7.00 |
| CHEMBL237088 | — | — | 1 | 7.00 |
| CHEMBL391494 | — | — | 1 | 6.70 |
| CHEMBL429632 | — | — | 1 | 6.68 |
| CHEMBL391709 | — | — | 1 | 6.60 |
| CHEMBL236465 | — | — | 1 | 6.58 |
| CHEMBL391708 | — | — | 1 | 6.57 |
| CHEMBL391511 | — | — | 1 | 6.50 |
| CHEMBL237309 | — | — | 1 | 6.47 |
| CHEMBL393200 | — | — | 1 | 6.39 |
| CHEMBL236667 | — | — | 1 | 6.35 |
| CHEMBL236879 | — | — | 1 | 6.26 |
| CHEMBL391495 | — | — | 1 | 6.14 |
| CHEMBL236464 | — | — | 1 | 6.07 |
| CHEMBL236666 | — | — | 1 | 5.77 |
| CHEMBL393199 | — | — | 1 | 5.72 |
| CHEMBL236880 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237310 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL237308 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL237088 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL391494 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL429632 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL391709 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL236465 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL391708 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL391511 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL237309 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL393200 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL236667 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL236879 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL391495 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL236464 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL236666 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL393199 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL236880 | — | IC50 | = | 2500.0 | nM | 5.60 |