Assay Detail
Binding
CHEMBL899145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]QNB from human muscarinic M4 receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.72 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275104 | — | — | 1 | 6.65 |
| CHEMBL239655 | — | — | 1 | 6.17 |
| CHEMBL398043 | — | — | 1 | 6.10 |
| CHEMBL239017 | — | — | 1 | 5.96 |
| CHEMBL239436 | — | — | 1 | 5.77 |
| CHEMBL396845 | — | — | 1 | 5.64 |
| CHEMBL428916 | — | — | 1 | 5.26 |
| CHEMBL238825 | — | — | 1 | 5.23 |
| CHEMBL239866 | — | — | 1 | 5.22 |
| CHEMBL239038 | — | — | 1 | 5.22 |
| CHEMBL394329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275104 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL239655 | — | Ki | = | 682.0 | nM | 6.17 |
| CHEMBL398043 | — | Ki | = | 792.0 | nM | 6.10 |
| CHEMBL239017 | — | Ki | = | 1095.0 | nM | 5.96 |
| CHEMBL239436 | — | Ki | = | 1681.0 | nM | 5.77 |
| CHEMBL396845 | — | Ki | = | 2265.0 | nM | 5.64 |
| CHEMBL428916 | — | Ki | = | 5478.0 | nM | 5.26 |
| CHEMBL238825 | — | Ki | = | 5932.0 | nM | 5.23 |
| CHEMBL239866 | — | Ki | = | 6041.0 | nM | 5.22 |
| CHEMBL239038 | — | Ki | = | 5986.0 | nM | 5.22 |
| CHEMBL394329 | — | Ki | > | 10000.0 | nM | - |