Assay Detail
Functional
CHEMBL899158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.01 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.22 |
| CHEMBL439053 | — | — | 1 | 4.42 |
| CHEMBL239296 | — | — | 1 | 4.25 |
| CHEMBL239075 | EUSCAPHIC ACID | — | 1 | 4.12 |
| CHEMBL239077 | TOMENTIC ACID | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL439053 | — | IC50 | = | 38350.0 | nM | 4.42 |
| CHEMBL239296 | — | IC50 | = | 56610.0 | nM | 4.25 |
| CHEMBL239075 | EUSCAPHIC ACID | IC50 | = | 76710.0 | nM | 4.12 |
| CHEMBL239077 | TOMENTIC ACID | IC50 | = | 89360.0 | nM | 4.05 |