Assay Detail
Binding
CHEMBL899400
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Inhibition of TC-PTP after 10 mins
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.33 | 4.66 |
| Ki | 1 | 5.09 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238138 | — | — | 2 | 5.09 |
| CHEMBL238137 | — | — | 1 | 4.43 |
| CHEMBL236636 | — | — | 1 | 4.36 |
| CHEMBL237915 | — | — | 1 | 4.19 |
| CHEMBL393866 | — | — | 1 | 4.02 |
| CHEMBL236216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238138 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL238138 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL238137 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL236636 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL237915 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL393866 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL236216 | — | IC50 | = | 120000.0 | nM | - |