Assay Detail
Functional
CHEMBL899466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 with reverse transcriptase K103N mutation in MT4 cells assessed as inhibition of viral induced cytopathic effect by MTT method
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 43 | 6.55 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239338 | — | — | 1 | 8.22 |
| CHEMBL396816 | — | — | 1 | 8.00 |
| CHEMBL239337 | — | — | 1 | 7.70 |
| CHEMBL240386 | — | — | 1 | 7.30 |
| CHEMBL238856 | — | — | 1 | 7.10 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.05 |
| CHEMBL239919 | — | — | 1 | 6.92 |
| CHEMBL394482 | — | — | 1 | 6.81 |
| CHEMBL393696 | — | — | 1 | 6.75 |
| CHEMBL239343 | — | — | 1 | 6.71 |
| CHEMBL236161 | — | — | 1 | 6.65 |
| CHEMBL238907 | — | — | 1 | 6.60 |
| CHEMBL442246 | — | — | 1 | 6.49 |
| CHEMBL239281 | — | — | 1 | 6.43 |
| CHEMBL239063 | — | — | 1 | 6.41 |
| CHEMBL239342 | — | — | 1 | 6.28 |
| CHEMBL394990 | — | — | 1 | 6.12 |
| CHEMBL239719 | — | — | 1 | 5.92 |
| CHEMBL239064 | — | — | 1 | 5.91 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.75 |
| CHEMBL238702 | — | — | 1 | 5.74 |
| CHEMBL239717 | — | — | 1 | 5.62 |
| CHEMBL239934 | — | — | 1 | 5.36 |
| CHEMBL239718 | — | — | 1 | 5.34 |
| CHEMBL240769 | — | — | 1 | - |
| CHEMBL239120 | — | — | 1 | - |
| CHEMBL238701 | — | — | 1 | - |
| CHEMBL238700 | — | — | 1 | - |
| CHEMBL427856 | — | — | 1 | - |
| CHEMBL397172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239338 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL396816 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL239337 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL240386 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL238856 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL239919 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL394482 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL393696 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL239343 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL236161 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL238907 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL442246 | — | EC50 | = | 322.0 | nM | 6.49 |
| CHEMBL239281 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL239063 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL239342 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL394990 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL239719 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL239064 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL238702 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL239717 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL239934 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL239718 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL391165 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL238882 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL396683 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL241666 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL238464 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL238921 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL239699 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL239918 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL391164 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL240770 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL391762 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL395404 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL238466 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL397172 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL427856 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL238700 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL238701 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL239120 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL240769 | — | EC50 | > | 10000.0 | nM | - |