Assay Detail
Functional
CHEMBL899618
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Inhibition of HCV replication in Huh7 cells after 48 hrs by luciferase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5'-O-masked 2'-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 4.58 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237643 | — | — | 1 | 5.21 |
| CHEMBL237453 | — | — | 1 | 5.19 |
| CHEMBL236326 | — | — | 1 | 5.08 |
| CHEMBL395167 | — | — | 1 | 4.88 |
| CHEMBL235479 | — | — | 1 | 4.75 |
| CHEMBL235493 | — | — | 1 | 4.65 |
| CHEMBL397623 | — | — | 1 | 4.61 |
| CHEMBL236325 | — | — | 1 | 4.55 |
| CHEMBL400607 | — | — | 1 | 4.54 |
| CHEMBL396828 | — | — | 1 | 4.52 |
| CHEMBL397974 | — | — | 1 | 4.51 |
| CHEMBL236117 | — | — | 1 | 4.42 |
| CHEMBL237454 | — | — | 1 | 4.39 |
| CHEMBL393297 | — | — | 1 | 4.34 |
| CHEMBL244379 | — | — | 1 | 4.33 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 4.26 |
| CHEMBL244380 | — | — | 1 | 4.19 |
| CHEMBL388932 | — | — | 1 | 4.09 |
| CHEMBL236532 | — | — | 1 | - |
| CHEMBL392954 | — | — | 1 | - |
| CHEMBL392122 | — | — | 1 | - |
| CHEMBL235495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237643 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL237453 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL236326 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL395167 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL235479 | — | EC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL235493 | — | EC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL397623 | — | EC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL236325 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL400607 | — | EC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL396828 | — | EC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL397974 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL236117 | — | EC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL237454 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL393297 | — | EC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL244379 | — | EC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 54800.0 | nM | 4.26 |
| CHEMBL244380 | — | EC50 | = | 64100.0 | nM | 4.19 |
| CHEMBL388932 | — | EC50 | = | 80800.0 | nM | 4.09 |
| CHEMBL236532 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL392954 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL392122 | — | EC50 | = | 105000.0 | nM | - |
| CHEMBL235495 | — | EC50 | > | 100000.0 | nM | - |