Assay Detail
Functional
CHEMBL899645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S binding
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.62 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236514 | — | — | 1 | 8.33 |
| CHEMBL393648 | — | — | 1 | 8.18 |
| CHEMBL237572 | — | — | 1 | 8.11 |
| CHEMBL396185 | — | — | 1 | 8.01 |
| CHEMBL237749 | — | — | 1 | 7.95 |
| CHEMBL236515 | — | — | 1 | 7.62 |
| CHEMBL393522 | — | — | 1 | 7.52 |
| CHEMBL237787 | — | — | 1 | 7.45 |
| CHEMBL237789 | — | — | 1 | 7.30 |
| CHEMBL397053 | — | — | 1 | 7.29 |
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 7.09 |
| CHEMBL392392 | — | — | 1 | 6.63 |
| CHEMBL236312 | — | — | 1 | - |
| CHEMBL236315 | — | — | 1 | - |
| CHEMBL237790 | — | — | 1 | - |
| CHEMBL238007 | — | — | 1 | - |
| CHEMBL410364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236514 | — | Ki | = | 4.65 | nM | 8.33 |
| CHEMBL393648 | — | Ki | = | 6.68 | nM | 8.18 |
| CHEMBL237572 | — | Ki | = | 7.84 | nM | 8.11 |
| CHEMBL396185 | — | Ki | = | 9.83 | nM | 8.01 |
| CHEMBL237749 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL236515 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL393522 | — | Ki | = | 29.9 | nM | 7.52 |
| CHEMBL237787 | — | Ki | = | 35.5 | nM | 7.45 |
| CHEMBL237789 | — | Ki | = | 49.8 | nM | 7.30 |
| CHEMBL397053 | — | Ki | = | 50.8 | nM | 7.29 |
| CHEMBL500 | PINDOLOL | Ki | = | 81.1 | nM | 7.09 |
| CHEMBL392392 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL236312 | — | Ki | - | — | - | |
| CHEMBL236315 | — | Ki | - | — | - | |
| CHEMBL237790 | — | Ki | - | — | - | |
| CHEMBL238007 | — | Ki | - | — | - | |
| CHEMBL410364 | — | Ki | - | — | - |