Assay Detail
Binding
CHEMBL899676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAMTS5 by FRET assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5 (CHEMBL2285) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.55 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237148 | — | — | 1 | 6.21 |
| CHEMBL401435 | — | — | 1 | 6.19 |
| CHEMBL236523 | — | — | 1 | 6.11 |
| CHEMBL237149 | — | — | 1 | 6.06 |
| CHEMBL237366 | — | — | 1 | 6.05 |
| CHEMBL237368 | — | — | 1 | 6.02 |
| CHEMBL236942 | — | — | 1 | 5.92 |
| CHEMBL236525 | — | — | 1 | 5.92 |
| CHEMBL236105 | — | — | 1 | 5.85 |
| CHEMBL236316 | — | — | 1 | 5.85 |
| CHEMBL393651 | — | — | 1 | 5.85 |
| CHEMBL237367 | — | — | 1 | 5.82 |
| CHEMBL235891 | — | — | 1 | 5.72 |
| CHEMBL236317 | — | — | 1 | 5.70 |
| CHEMBL236318 | — | — | 1 | 5.62 |
| CHEMBL392395 | — | — | 1 | 5.60 |
| CHEMBL428379 | — | — | 1 | 5.58 |
| CHEMBL391124 | — | — | 1 | 5.52 |
| CHEMBL400202 | — | — | 1 | 5.51 |
| CHEMBL235890 | — | — | 1 | 5.43 |
| CHEMBL400201 | — | — | 1 | 5.36 |
| CHEMBL444891 | — | — | 1 | 5.34 |
| CHEMBL235889 | — | — | 1 | 5.14 |
| CHEMBL236944 | — | — | 1 | 5.12 |
| CHEMBL391123 | — | — | 1 | 5.02 |
| CHEMBL394936 | — | — | 1 | 4.96 |
| CHEMBL236106 | — | — | 1 | 4.87 |
| CHEMBL238012 | — | — | 1 | 4.87 |
| CHEMBL393652 | — | — | 1 | 4.62 |
| CHEMBL438674 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237148 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL401435 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL236523 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL237149 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL237366 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL237368 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL236942 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL236525 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL236105 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL236316 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL393651 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL237367 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL235891 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL236317 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL236318 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL392395 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL428379 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL391124 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL400202 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL235890 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL400201 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL444891 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL235889 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL236944 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL391123 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL394936 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL236106 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL238012 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL393652 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL438674 | — | IC50 | = | 24200.0 | nM | 4.62 |