Assay Detail
Functional
CHEMBL899691
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Antiproliferative activity against human HCT116 cells
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative activity of chalcones with basic functionalities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 4.94 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241592 | — | — | 1 | 5.64 |
| CHEMBL238842 | — | — | 1 | 5.58 |
| CHEMBL239884 | — | — | 1 | 5.54 |
| CHEMBL239268 | — | — | 1 | 5.52 |
| CHEMBL238841 | — | — | 1 | 5.51 |
| CHEMBL241799 | — | — | 1 | 5.48 |
| CHEMBL241161 | — | — | 1 | 5.47 |
| CHEMBL241800 | — | — | 1 | 5.44 |
| CHEMBL393468 | — | — | 1 | 5.41 |
| CHEMBL239267 | — | — | 1 | 5.38 |
| CHEMBL73090 | — | — | 1 | 5.36 |
| CHEMBL393447 | — | — | 1 | 5.31 |
| CHEMBL241781 | — | — | 1 | 5.28 |
| CHEMBL138662 | — | — | 1 | 5.21 |
| CHEMBL428208 | — | — | 1 | 5.18 |
| CHEMBL239445 | — | — | 1 | 5.17 |
| CHEMBL429636 | — | — | 1 | 5.17 |
| CHEMBL238608 | — | — | 1 | 5.16 |
| CHEMBL239269 | — | — | 1 | 5.16 |
| CHEMBL239689 | — | — | 1 | 5.13 |
| CHEMBL240097 | — | — | 1 | 5.13 |
| CHEMBL239446 | — | — | 1 | 5.12 |
| CHEMBL400440 | — | — | 1 | 5.11 |
| CHEMBL391282 | — | — | 1 | 5.11 |
| CHEMBL394395 | — | — | 1 | 5.08 |
| CHEMBL397797 | — | — | 1 | 5.07 |
| CHEMBL238840 | — | — | 1 | 5.06 |
| CHEMBL238623 | — | — | 1 | 5.03 |
| CHEMBL239660 | — | — | 1 | 5.00 |
| CHEMBL239886 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241592 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL238842 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL239884 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL239268 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL238841 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL241799 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL241161 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL241800 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL393468 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL239267 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL73090 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL393447 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL241781 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL138662 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL428208 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL239445 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL429636 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL238608 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL239269 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL239689 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL240097 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL239446 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL400440 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL391282 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL394395 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL397797 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL238840 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL238623 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL239660 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL239886 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL392412 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL239476 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL238838 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL238622 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL239908 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL241782 | DILMEFONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL241377 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL239691 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL393748 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL400441 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL397104 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL240311 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL241162 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL239237 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL392072 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL238837 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL393527 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL239236 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL392192 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL240310 | — | IC50 | = | 19300.0 | nM | 4.71 |