Assay Detail
Binding
CHEMBL899826
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Inhibition of Tie2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of triarylimidazoles for Tie2: influence of conformation on potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.82 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237570 | — | — | 1 | 7.92 |
| CHEMBL2096892 | — | — | 1 | 7.66 |
| CHEMBL236716 | — | — | 1 | 7.44 |
| CHEMBL391891 | — | — | 1 | 7.40 |
| CHEMBL236924 | — | — | 1 | 7.29 |
| CHEMBL392332 | — | — | 1 | 7.23 |
| CHEMBL399410 | — | — | 1 | 7.22 |
| CHEMBL236503 | — | — | 1 | 7.11 |
| CHEMBL236300 | — | — | 1 | 7.09 |
| CHEMBL2448122 | — | — | 1 | 7.02 |
| CHEMBL237571 | — | — | 1 | 6.94 |
| CHEMBL236299 | — | — | 1 | 6.80 |
| CHEMBL391890 | — | — | 1 | 6.60 |
| CHEMBL391889 | — | — | 1 | 6.58 |
| CHEMBL237359 | — | — | 1 | 6.47 |
| CHEMBL236504 | — | — | 1 | 6.46 |
| CHEMBL236686 | — | — | 1 | 6.41 |
| CHEMBL236505 | — | — | 1 | 6.08 |
| CHEMBL236715 | — | — | 1 | 5.89 |
| CHEMBL236717 | — | — | 1 | 5.82 |
| CHEMBL236298 | — | — | 1 | 5.80 |
| CHEMBL237352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237570 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2096892 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL236716 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL391891 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL236924 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL392332 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL399410 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL236503 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL236300 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2448122 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL237571 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL236299 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL391890 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL391889 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL237359 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL236504 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL236686 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL236505 | — | IC50 | = | 836.0 | nM | 6.08 |
| CHEMBL236715 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL236717 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL236298 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL237352 | — | IC50 | > | 20000.0 | nM | - |