Assay Detail
Functional
CHEMBL900091
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Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New iantherans from the marine sponge Ianthella quadrangulata: novel agonists of the P2Y(11) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.47 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131890 | ATPGAMMAS | — | 1 | 7.20 |
| CHEMBL394381 | 8-CARBOXY-ISO-IANTHERAN A | — | 1 | 6.32 |
| CHEMBL240681 | ISO-IANTHERAN A | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131890 | ATPGAMMAS | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL394381 | 8-CARBOXY-ISO-IANTHERAN A | EC50 | = | 478.63 | nM | 6.32 |
| CHEMBL240681 | ISO-IANTHERAN A | EC50 | = | 1288.25 | nM | 5.89 |