Assay Detail
Functional
CHEMBL900126
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Cytotoxicity against human HCT116 cells by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.69 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235210 | — | — | 1 | 6.40 |
| CHEMBL235842 | — | — | 1 | 6.30 |
| CHEMBL393242 | — | — | 1 | 6.05 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.40 |
| CHEMBL236061 | — | — | 1 | 5.00 |
| CHEMBL236060 | — | — | 1 | 4.96 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235210 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL235842 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL393242 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL236061 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL236060 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL356066 | DACINOSTAT | IC50 | < | 50.0 | nM | - |