Assay Detail
Binding
CHEMBL900177
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Inhibition of human Acetylcholinesterase
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.63 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540131 | — | — | 1 | 8.26 |
| CHEMBL555247 | — | — | 1 | 8.18 |
| CHEMBL540132 | — | — | 1 | 8.17 |
| CHEMBL1203985 | — | — | 1 | 8.12 |
| CHEMBL1203986 | — | — | 1 | 7.80 |
| CHEMBL1203984 | — | — | 2 | 7.63 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 6.87 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.03 |
| CHEMBL360055 | GALLAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540131 | — | IC50 | = | 5.44 | nM | 8.26 |
| CHEMBL555247 | — | IC50 | = | 6.54 | nM | 8.18 |
| CHEMBL540132 | — | IC50 | = | 6.75 | nM | 8.17 |
| CHEMBL1203985 | — | IC50 | = | 7.61 | nM | 8.12 |
| CHEMBL1203986 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL1203984 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL95 | TACRINE | IC50 | = | 926.0 | nM | 6.03 |
| CHEMBL360055 | GALLAMINE | IC50 | = | 2110000.0 | nM | - |
| CHEMBL1203984 | — | IC50 | = | 1480000.0 | nM | - |