Assay Detail
Binding
CHEMBL900179
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Inhibition of p38 MAPK activity assessed as EGFR phosphorylation
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.18 | 7.92 |
| Kd | 1 | 7.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237817 | — | — | 1 | 7.92 |
| CHEMBL279416 | VK-19911 | — | 1 | 7.82 |
| CHEMBL396320 | — | — | 1 | 7.80 |
| CHEMBL274064 | SB-220025 | — | 1 | 7.72 |
| CHEMBL236559 | — | — | 1 | 7.40 |
| CHEMBL237606 | — | — | 1 | 7.30 |
| CHEMBL237602 | — | — | 1 | 7.21 |
| CHEMBL391277 | — | — | 1 | 6.96 |
| CHEMBL236356 | — | — | 1 | 6.89 |
| CHEMBL236557 | — | — | 1 | 6.89 |
| CHEMBL400030 | — | — | 1 | 6.72 |
| CHEMBL236558 | — | — | 1 | 6.72 |
| CHEMBL400029 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237817 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL279416 | VK-19911 | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL396320 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL274064 | SB-220025 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL236559 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL237606 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL237602 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL391277 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL236356 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL236557 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL400030 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL236558 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL400029 | — | IC50 | = | 260.0 | nM | 6.58 |