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Assay Detail

CHEMBL900367

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Functional
Antiprotozoal activity against Leishmania chagasi PP75 in vero cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania chagasi
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania chagasi (CHEMBL612790)
Type ORGANISM
Organism Leishmania chagasi

Publication

Synthesis and in vitro evaluation of leishmanicidal and trypanocidal activities of N-quinolin-8-yl-arylsulfonamides.
da Silva LE, Joussef AC, Pacheco LK, da Silva DG, Steindel M, Rebelo RA, Schmidt B.
Bioorg Med Chem (2007) 15 : 7553 -7560
PubMed 17889546 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.87 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.60
CHEMBL239272 1 6.35
CHEMBL394918 1 6.28
CHEMBL240549 1 6.25
CHEMBL240550 1 5.66
CHEMBL239478 1 5.52
CHEMBL391343 1 5.45
CHEMBL392413 1 4.86
CHEMBL540966 1 -
CHEMBL240130 1 -
CHEMBL394919 1 -
CHEMBL397804 1 -
CHEMBL393749 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 250.0 nM 6.60
CHEMBL239272 IC50 = 450.0 nM 6.35
CHEMBL394918 IC50 = 530.0 nM 6.28
CHEMBL240549 IC50 = 560.0 nM 6.25
CHEMBL240550 IC50 = 2180.0 nM 5.66
CHEMBL239478 IC50 = 2990.0 nM 5.52
CHEMBL391343 IC50 = 3530.0 nM 5.45
CHEMBL392413 IC50 = 13960.0 nM 4.86
CHEMBL540966 IC50 > 100000.0 nM -
CHEMBL240130 IC50 > 100000.0 nM -
CHEMBL394919 IC50 > 100000.0 nM -
CHEMBL397804 IC50 > 100000.0 nM -
CHEMBL393749 IC50 > 100000.0 nM -