Assay Detail
Functional
CHEMBL900399
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Antiproliferative activity against H661 cells after 48 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H661 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.66 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.07 |
| CHEMBL424753 | — | — | 1 | 6.52 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.30 |
| CHEMBL395138 | — | — | 1 | 4.70 |
| CHEMBL236945 | — | — | 1 | 4.70 |
| CHEMBL237975 | — | — | 1 | - |
| CHEMBL237974 | — | — | 1 | - |
| CHEMBL236738 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL424753 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL395138 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL236945 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL237975 | — | IC50 | >= | 25000.0 | nM | - |
| CHEMBL237974 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL236738 | — | IC50 | > | 25000.0 | nM | - |