Assay Detail
Functional
CHEMBL900416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.90 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.52 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.40 |
| CHEMBL279962 | — | — | 1 | 8.10 |
| CHEMBL238650 | — | — | 1 | 7.96 |
| CHEMBL395618 | — | — | 1 | 7.82 |
| CHEMBL239548 | — | — | 1 | 7.72 |
| CHEMBL239124 | — | — | 1 | 7.51 |
| CHEMBL399202 | — | — | 1 | 7.51 |
| CHEMBL238919 | — | — | 1 | 7.40 |
| CHEMBL395407 | — | — | 1 | 7.29 |
| CHEMBL239125 | — | — | 1 | 7.22 |
| CHEMBL427855 | — | — | 1 | 7.14 |
| CHEMBL167845 | — | — | 1 | 7.14 |
| CHEMBL239072 | — | — | 1 | 7.11 |
| CHEMBL393934 | — | — | 1 | 7.09 |
| CHEMBL239290 | — | — | 1 | 7.08 |
| CHEMBL238920 | — | — | 1 | 7.05 |
| CHEMBL239759 | — | — | 1 | 7.00 |
| CHEMBL238864 | — | — | 1 | 7.00 |
| CHEMBL239071 | — | — | 1 | 6.98 |
| CHEMBL393935 | — | — | 1 | 6.92 |
| CHEMBL239498 | — | — | 1 | 6.92 |
| CHEMBL239758 | — | — | 1 | 6.91 |
| CHEMBL238651 | — | — | 1 | 6.90 |
| CHEMBL238715 | — | — | 1 | 6.90 |
| CHEMBL399201 | — | — | 1 | 6.88 |
| CHEMBL395406 | — | — | 1 | 6.84 |
| CHEMBL238714 | — | — | 1 | 6.83 |
| CHEMBL392503 | — | — | 1 | 6.80 |
| CHEMBL238865 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL279962 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL238650 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL395618 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL239548 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL239124 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL399202 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL238919 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL395407 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL239125 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL167845 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL427855 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL239072 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL393934 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL239290 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL238920 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL239759 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL238864 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL239071 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL393935 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL239498 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL239758 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL238715 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL238651 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL399201 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL395406 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL238714 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL392503 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL238865 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL391462 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL239752 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL239083 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1203948 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL392502 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL238863 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL399403 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL239073 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL239339 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL239966 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL239968 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL239289 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL238713 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL394190 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL239753 | — | IC50 | = | 18700.0 | nM | 4.73 |