Assay Detail
Functional
CHEMBL900550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL43 in MT4 cells assessed as inhibition of viral induced cytopathic effect after 4 days by MTT method
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 61 | 7.73 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240386 | — | — | 1 | 9.52 |
| CHEMBL239337 | — | — | 1 | 9.52 |
| CHEMBL239338 | — | — | 1 | 9.30 |
| CHEMBL396816 | — | — | 1 | 9.22 |
| CHEMBL238856 | — | — | 1 | 9.22 |
| CHEMBL239919 | — | — | 1 | 9.00 |
| CHEMBL236161 | — | — | 1 | 9.00 |
| CHEMBL239719 | — | — | 1 | 8.70 |
| CHEMBL394482 | — | — | 1 | 8.70 |
| CHEMBL238907 | — | — | 1 | 8.70 |
| CHEMBL393696 | — | — | 1 | 8.70 |
| CHEMBL394990 | — | — | 1 | 8.70 |
| CHEMBL442246 | — | — | 1 | 8.70 |
| CHEMBL239063 | — | — | 1 | 8.70 |
| CHEMBL239281 | — | — | 1 | 8.52 |
| CHEMBL239064 | — | — | 1 | 8.52 |
| CHEMBL395404 | — | — | 1 | 8.52 |
| CHEMBL239343 | — | — | 1 | 8.52 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.40 |
| CHEMBL239120 | — | — | 1 | 8.40 |
| CHEMBL239717 | — | — | 1 | 8.30 |
| CHEMBL240388 | — | — | 1 | 8.22 |
| CHEMBL239342 | — | — | 1 | 8.15 |
| CHEMBL238702 | — | — | 1 | 8.15 |
| CHEMBL238882 | — | — | 1 | 8.10 |
| CHEMBL393110 | — | — | 1 | 8.05 |
| CHEMBL238466 | — | — | 1 | 8.05 |
| CHEMBL239743 | — | — | 1 | 8.05 |
| CHEMBL239934 | — | — | 1 | 8.05 |
| CHEMBL399016 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240386 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL239337 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL239338 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL396816 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL238856 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL239919 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL236161 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL239063 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL442246 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL394990 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL238907 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL394482 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL239719 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL393696 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL239343 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL239281 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL395404 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL239064 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL239120 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL239717 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL240388 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL239342 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL238702 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL238882 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL393110 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL239934 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL238466 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL239743 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL399016 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL241666 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL391165 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL239718 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL397172 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL239918 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL391164 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL238701 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL239940 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL240387 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL238921 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL391762 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL240770 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL239699 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL238700 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL239939 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL396683 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL427856 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL238464 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL438132 | — | EC50 | = | 133.0 | nM | 6.88 |