Assay Detail
Binding
CHEMBL900871
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Displacement of [3H]-N-alpha methyl histamine from rat H3 receptor expressed in C6 cells
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.98 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237394 | — | — | 2 | 9.31 |
| CHEMBL237191 | — | — | 2 | 9.14 |
| CHEMBL393581 | — | — | 2 | 9.04 |
| CHEMBL392573 | — | — | 2 | 9.03 |
| CHEMBL351231 | — | — | 2 | 8.87 |
| CHEMBL442242 | — | — | 2 | 8.79 |
| CHEMBL263101 | — | — | 2 | 8.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237394 | — | Ki | = | 0.4898 | nM | 9.31 |
| CHEMBL237394 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL237191 | — | Ki | = | 0.7244 | nM | 9.14 |
| CHEMBL237191 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL393581 | — | Ki | = | 0.912 | nM | 9.04 |
| CHEMBL393581 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL392573 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL392573 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL351231 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL351231 | — | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL442242 | — | Ki | = | 1.622 | nM | 8.79 |
| CHEMBL442242 | — | Ki | = | 1.62 | nM | 8.79 |
| CHEMBL263101 | — | Ki | = | 1.95 | nM | 8.71 |
| CHEMBL263101 | — | Ki | = | 1.95 | nM | 8.71 |