Assay Detail
Functional
CHEMBL900987
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Agonist activity at guinea pig mu-opioid receptor by GPI assay
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.17 | 8.07 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235109 | — | — | 1 | 8.07 |
| CHEMBL235743 | — | — | 1 | 7.33 |
| CHEMBL235107 | — | — | 1 | 7.33 |
| CHEMBL392206 | — | — | 1 | 7.02 |
| CHEMBL439026 | — | — | 1 | 6.92 |
| CHEMBL235106 | — | — | 1 | 6.80 |
| CHEMBL392207 | — | — | 1 | 6.70 |
| CHEMBL216239 | CARBOXYFENTANYL | — | 1 | - |
| CHEMBL392185 | — | — | 1 | - |
| CHEMBL235108 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235109 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL235743 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL235107 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL392206 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL439026 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL235106 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL392207 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL216239 | CARBOXYFENTANYL | Activity | = | - | % | - |
| CHEMBL392185 | — | Activity | = | 15.0 | % | - |
| CHEMBL235108 | — | Activity | = | 3.0 | % | - |