Assay Detail
Binding
CHEMBL901401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX1 in human whole blood assessed as effect on A23187-induced thromboxane B2 production
31
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.41 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL393680 | — | — | 1 | 5.92 |
| CHEMBL237399 | — | — | 1 | 5.80 |
| CHEMBL235027 | — | — | 1 | 5.72 |
| CHEMBL237033 | — | — | 1 | 5.64 |
| CHEMBL24837 | — | — | 1 | 5.62 |
| CHEMBL399198 | — | — | 1 | 5.58 |
| CHEMBL295829 | OXAMETACIN | 2.0 | 1 | 5.55 |
| CHEMBL237022 | — | — | 1 | 5.52 |
| CHEMBL25725 | — | — | 1 | 5.48 |
| CHEMBL429267 | — | — | 1 | 5.44 |
| CHEMBL237208 | — | — | 2 | 5.43 |
| CHEMBL237204 | — | — | 1 | 5.33 |
| CHEMBL237398 | — | — | 1 | 5.27 |
| CHEMBL237021 | — | — | 1 | 5.22 |
| CHEMBL237207 | — | — | 2 | 4.96 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.85 |
| CHEMBL800 | — | — | 1 | 4.81 |
| CHEMBL237400 | — | — | 1 | 4.80 |
| CHEMBL400428 | — | — | 1 | - |
| CHEMBL237402 | — | — | 1 | - |
| CHEMBL238240 | — | — | 1 | - |
| CHEMBL557174 | — | — | 1 | - |
| CHEMBL237412 | — | — | 1 | - |
| CHEMBL421385 | — | — | 1 | - |
| CHEMBL391223 | — | — | 1 | - |
| CHEMBL237205 | — | — | 1 | - |
| CHEMBL393127 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL393680 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL237399 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL235027 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL237033 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL24837 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL399198 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL295829 | OXAMETACIN | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL237022 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL25725 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL429267 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL237208 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL237208 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL237204 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL237398 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL237021 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL237207 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL237207 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL118 | CELECOXIB | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL800 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL237400 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL400428 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL237402 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL238240 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL557174 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL393127 | — | IC50 | < | 300.0 | nM | - |
| CHEMBL237412 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL421385 | — | IC50 | < | 300.0 | nM | - |
| CHEMBL391223 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL237205 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL393127 | — | IC50 | < | 300.0 | nM | - |