Assay Detail
Binding
CHEMBL901432
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Inhibition of human recombinant NQO1
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312727 | — | — | 1 | 8.30 |
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 8.30 |
| CHEMBL312008 | — | — | 1 | 7.00 |
| CHEMBL293914 | — | — | 1 | 6.96 |
| CHEMBL316387 | — | — | 1 | 6.85 |
| CHEMBL237186 | — | — | 1 | 6.82 |
| CHEMBL32926 | — | — | 1 | 6.70 |
| CHEMBL238294 | — | — | 1 | 6.66 |
| CHEMBL391213 | — | — | 1 | 6.60 |
| CHEMBL32711 | — | — | 1 | 6.60 |
| CHEMBL284384 | — | — | 1 | 6.46 |
| CHEMBL81144 | — | — | 1 | 6.42 |
| CHEMBL315955 | — | — | 1 | 6.30 |
| CHEMBL82228 | — | — | 1 | 6.26 |
| CHEMBL83968 | — | — | 1 | 6.19 |
| CHEMBL80104 | — | — | 1 | 6.06 |
| CHEMBL84518 | — | — | 1 | 5.90 |
| CHEMBL309505 | — | — | 1 | 5.89 |
| CHEMBL82696 | — | — | 1 | 5.77 |
| CHEMBL237187 | — | — | 1 | 5.66 |
| CHEMBL262114 | — | — | 1 | 5.64 |
| CHEMBL240482 | — | — | 1 | 5.49 |
| CHEMBL1904453 | — | — | 1 | 5.46 |
| CHEMBL313509 | — | — | 1 | 5.38 |
| CHEMBL310188 | — | — | 1 | 5.12 |
| CHEMBL84340 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312727 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1466 | DICUMAROL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL312008 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL293914 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL316387 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL237186 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL32926 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL238294 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL391213 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL32711 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL284384 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL81144 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL315955 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL82228 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL83968 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL80104 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL84518 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL309505 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL82696 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL237187 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL262114 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL240482 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL1904453 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL313509 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL310188 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL84340 | — | IC50 | = | 8000.0 | nM | 5.10 |