Assay Detail
Binding
CHEMBL901433
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Inhibition of human recombinant NQO1 in presence of BSA
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.90 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312727 | — | — | 1 | 6.46 |
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 6.35 |
| CHEMBL391213 | — | — | 1 | 6.22 |
| CHEMBL32926 | — | — | 1 | 6.19 |
| CHEMBL309505 | — | — | 1 | 5.23 |
| CHEMBL316387 | — | — | 1 | 5.07 |
| CHEMBL238294 | — | — | 1 | 5.06 |
| CHEMBL82228 | — | — | 1 | 5.00 |
| CHEMBL83968 | — | — | 1 | 5.00 |
| CHEMBL240482 | — | — | 1 | 4.89 |
| CHEMBL81144 | — | — | 1 | 4.75 |
| CHEMBL293914 | — | — | 1 | 4.70 |
| CHEMBL312008 | — | — | 1 | 4.70 |
| CHEMBL313509 | — | — | 1 | 4.68 |
| CHEMBL82696 | — | — | 1 | 4.68 |
| CHEMBL315955 | — | — | 1 | 4.65 |
| CHEMBL84340 | — | — | 1 | 4.62 |
| CHEMBL237187 | — | — | 1 | 4.55 |
| CHEMBL1904453 | — | — | 1 | 4.54 |
| CHEMBL262114 | — | — | 1 | 4.46 |
| CHEMBL237186 | — | — | 1 | 4.39 |
| CHEMBL80104 | — | — | 1 | 4.35 |
| CHEMBL84518 | — | — | 1 | 4.30 |
| CHEMBL32711 | — | — | 1 | 4.26 |
| CHEMBL284384 | — | — | 1 | 4.22 |
| CHEMBL310188 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312727 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1466 | DICUMAROL | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL391213 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL32926 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL309505 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL316387 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL238294 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL82228 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL83968 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL240482 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL81144 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL293914 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL312008 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL313509 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL82696 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL315955 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL84340 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL237187 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1904453 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL262114 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL237186 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL80104 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL84518 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL32711 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL284384 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL310188 | — | IC50 | = | 82000.0 | nM | 4.09 |