Assay Detail
Binding
CHEMBL901476
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Displacement of [3H]GBR from DAT in rat brain membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.42 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247284 | — | — | 1 | 7.85 |
| CHEMBL245638 | — | — | 1 | 6.73 |
| CHEMBL245639 | — | — | 1 | 6.68 |
| CHEMBL393236 | — | — | 1 | 6.64 |
| CHEMBL396328 | — | — | 1 | 6.39 |
| CHEMBL245637 | — | — | 1 | 6.14 |
| CHEMBL439030 | — | — | 1 | 6.13 |
| CHEMBL429658 | — | — | 1 | 5.73 |
| CHEMBL394965 | — | — | 1 | 5.50 |
| CHEMBL247687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247284 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL245638 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL245639 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL393236 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL396328 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL245637 | — | Ki | = | 716.0 | nM | 6.14 |
| CHEMBL439030 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL429658 | — | Ki | = | 1871.0 | nM | 5.73 |
| CHEMBL394965 | — | Ki | = | 3139.0 | nM | 5.50 |
| CHEMBL247687 | — | Ki | > | 10000.0 | nM | - |