Assay Detail
Binding
CHEMBL901477
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Displacement of [3H]nisoxetine from NET in rat brain membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.61 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393236 | — | — | 1 | 9.08 |
| CHEMBL396328 | — | — | 1 | 8.61 |
| CHEMBL247687 | — | — | 1 | 7.81 |
| CHEMBL439030 | — | — | 1 | 7.56 |
| CHEMBL394965 | — | — | 1 | 7.54 |
| CHEMBL247284 | — | — | 1 | 7.15 |
| CHEMBL245638 | — | — | 1 | 7.14 |
| CHEMBL245637 | — | — | 1 | 7.13 |
| CHEMBL245639 | — | — | 1 | 7.10 |
| CHEMBL429658 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393236 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL396328 | — | Ki | = | 2.47 | nM | 8.61 |
| CHEMBL247687 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL439030 | — | Ki | = | 27.6 | nM | 7.56 |
| CHEMBL394965 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL247284 | — | Ki | = | 70.4 | nM | 7.15 |
| CHEMBL245638 | — | Ki | = | 71.9 | nM | 7.14 |
| CHEMBL245637 | — | Ki | = | 73.8 | nM | 7.13 |
| CHEMBL245639 | — | Ki | = | 79.6 | nM | 7.10 |
| CHEMBL429658 | — | Ki | = | 101.0 | nM | 7.00 |