Assay Detail
Functional
CHEMBL901498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 in blood
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.20 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.00 |
| CHEMBL241634 | — | — | 1 | 6.00 |
| CHEMBL238442 | — | — | 1 | 5.96 |
| CHEMBL394241 | — | — | 1 | 5.54 |
| CHEMBL241427 | — | — | 1 | 5.50 |
| CHEMBL394474 | — | — | 1 | 5.39 |
| CHEMBL241431 | — | — | 1 | 5.36 |
| CHEMBL241637 | — | — | 1 | 5.23 |
| CHEMBL238441 | — | — | 1 | 4.99 |
| CHEMBL238438 | — | — | 1 | 4.75 |
| CHEMBL238433 | — | — | 1 | 4.72 |
| CHEMBL238432 | — | — | 1 | 4.68 |
| CHEMBL394652 | — | — | 1 | 4.59 |
| CHEMBL241638 | — | — | 1 | 4.54 |
| CHEMBL241426 | — | — | 1 | 4.54 |
| CHEMBL396680 | — | — | 1 | 4.34 |
| CHEMBL241633 | — | — | 1 | 4.29 |
| CHEMBL241632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL241634 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL238442 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL394241 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL241427 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL394474 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL241431 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL241637 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL238441 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL238438 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL238433 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL238432 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL394652 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL241638 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL241426 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL396680 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL241633 | — | IC50 | = | 51400.0 | nM | 4.29 |
| CHEMBL241632 | — | IC50 | = | 223800.0 | nM | - |