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Assay Detail

CHEMBL901503

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ADMET
Cytotoxicity against rat L6 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.
Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R.
J Med Chem (2007) 50 : 5833 -5839
PubMed 17949068 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.82 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 8.00
CHEMBL238442 1 4.75
CHEMBL394241 1 4.52
CHEMBL241633 1 4.46
CHEMBL241632 1 4.39
CHEMBL238441 1 4.21
CHEMBL241634 1 4.21
CHEMBL241427 1 4.05
CHEMBL238432 1 -
CHEMBL394652 1 -
CHEMBL238433 1 -
CHEMBL241426 1 -
CHEMBL394474 1 -
CHEMBL396680 1 -
CHEMBL241431 1 -
CHEMBL241637 1 -
CHEMBL241638 1 -
CHEMBL238438 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 10.0 nM 8.00
CHEMBL238442 IC50 = 18000.0 nM 4.75
CHEMBL394241 IC50 = 30000.0 nM 4.52
CHEMBL241633 IC50 = 34500.0 nM 4.46
CHEMBL241632 IC50 = 40500.0 nM 4.39
CHEMBL238441 IC50 = 61600.0 nM 4.21
CHEMBL241634 IC50 = 61600.0 nM 4.21
CHEMBL241427 IC50 = 89600.0 nM 4.05
CHEMBL238432 IC50 = 201500.0 nM -
CHEMBL394652 IC50 = 231000.0 nM -
CHEMBL238433 IC50 = 112300.0 nM -
CHEMBL241426 IC50 = 164600.0 nM -
CHEMBL394474 IC50 = 149700.0 nM -
CHEMBL396680 IC50 = 155800.0 nM -
CHEMBL241431 IC50 > 245000.0 nM -
CHEMBL241637 IC50 = 171900.0 nM -
CHEMBL241638 IC50 > 203000.0 nM -
CHEMBL238438 IC50 > 267000.0 nM -