Assay Detail
Binding
CHEMBL901581
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Inhibition of human IMPDH type 2
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.14 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 8.15 |
| CHEMBL392203 | — | — | 1 | 7.85 |
| CHEMBL409560 | — | — | 1 | 7.57 |
| CHEMBL392204 | — | — | 1 | 7.42 |
| CHEMBL235533 | — | — | 1 | 7.31 |
| CHEMBL394277 | — | — | 1 | 7.08 |
| CHEMBL429702 | — | — | 1 | 7.03 |
| CHEMBL410745 | — | — | 1 | 6.97 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | — | 1 | 6.96 |
| CHEMBL264107 | — | — | 1 | 6.84 |
| CHEMBL441190 | — | — | 1 | 6.82 |
| CHEMBL265870 | — | — | 1 | 6.77 |
| CHEMBL410744 | — | — | 1 | 6.60 |
| CHEMBL414564 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL392203 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL409560 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL392204 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL235533 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL394277 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL429702 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL410745 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL264107 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL441190 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL265870 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL410744 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL414564 | — | Ki | = | 255.0 | nM | 6.59 |