Assay Detail
Functional
CHEMBL901585
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Antiproliferative activity against human K562 cells after 72 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.44 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392204 | — | — | 1 | 6.00 |
| CHEMBL410745 | — | — | 1 | 5.96 |
| CHEMBL410744 | — | — | 1 | 5.24 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 5.11 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392204 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL410745 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL410744 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL394276 | TIAZOFURIN ADENINE DINUCLEOTIDE | IC50 | = | 12400.0 | nM | 4.91 |