Assay Detail
Binding
CHEMBL901923
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Inhibition of porcine brain tubulin polymerization
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.21 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 6.89 |
| CHEMBL429265 | — | — | 1 | 6.54 |
| CHEMBL240468 | — | — | 1 | 6.54 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.46 |
| CHEMBL237880 | — | — | 1 | 6.41 |
| CHEMBL394754 | — | — | 1 | 6.15 |
| CHEMBL391497 | — | — | 1 | 6.13 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.12 |
| CHEMBL238102 | — | — | 1 | 6.04 |
| CHEMBL236411 | — | — | 1 | 6.03 |
| CHEMBL236993 | — | — | 1 | 5.98 |
| CHEMBL392633 | — | — | 1 | 5.92 |
| CHEMBL236992 | — | — | 1 | 5.90 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.85 |
| CHEMBL437381 | — | — | 1 | - |
| CHEMBL396891 | — | — | 1 | - |
| CHEMBL239833 | — | — | 1 | - |
| CHEMBL236412 | — | — | 1 | - |
| CHEMBL236584 | — | — | 1 | - |
| CHEMBL391432 | — | — | 1 | - |
| CHEMBL236601 | — | — | 1 | - |
| CHEMBL236776 | — | — | 1 | - |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL429265 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL240468 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL61 | PODOFILOX | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL237880 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL394754 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL391497 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL238102 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL236411 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL236993 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL392633 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL236992 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL437381 | — | IC50 | - | — | - | |
| CHEMBL396891 | — | IC50 | > | 14000.0 | nM | - |
| CHEMBL239833 | — | IC50 | > | 14000.0 | nM | - |
| CHEMBL236412 | — | IC50 | - | — | - | |
| CHEMBL236584 | — | IC50 | - | — | - | |
| CHEMBL391432 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL236601 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL236776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | - | — | - |