Assay Detail
Binding
CHEMBL901924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]colchicine from biotinylated tubulin by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.17 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238102 | — | — | 1 | 6.29 |
| CHEMBL392633 | — | — | 1 | 6.25 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238102 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL392633 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1050.0 | nM | 5.98 |