Assay Detail
Functional
CHEMBL901937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.33 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.62 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.85 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.31 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.04 |
| CHEMBL238102 | — | — | 1 | 6.90 |
| CHEMBL392633 | — | — | 1 | 6.87 |
| CHEMBL116173 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL107 | COLCHICINE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL428647 | PACLITAXEL | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL9514 | NOCODAZOLE | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL238102 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL392633 | — | EC50 | = | 135.0 | nM | 6.87 |
| CHEMBL116173 | — | EC50 | = | 200.0 | nM | 6.70 |