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Assay Detail

CHEMBL902052

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Functional
Inhibition of acid secretion in rabbit intact gastric glands assessed as [14C]dimethylaminopyridine accumulation
ChEMBL ↗
54
Total Activities
54
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Gastric gland
Confidence 1 — Organism
Curated By Autocuration

Target

Gastric gland (CHEMBL613448) ↗
Type TISSUE
Organism Oryctolagus cuniculus

Publication

Synthesis and evaluation of 7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridines as potassium-competitive acid blockers.
Palmer AM, Grobbel B, Jecke C, Brehm C, Zimmermann PJ, Buhr W, Feth MP, Simon WA, Kromer W.
J Med Chem (2007) 50 : 6240 -6264
PubMed 17975907 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 5.96 7.30
Activity 7 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL394240 — — 1 7.30
CHEMBL391255 — — 1 7.10
CHEMBL392580 — — 1 7.00
CHEMBL391054 — — 1 6.80
CHEMBL393803 — — 1 6.70
CHEMBL240781 — — 1 6.70
CHEMBL391059 — — 1 6.70
CHEMBL241005 — — 1 6.70
CHEMBL392764 — — 1 6.60
CHEMBL238692 — — 1 6.60
CHEMBL238691 — — 1 6.60
CHEMBL241009 — — 1 6.50
CHEMBL393217 — — 1 6.50
CHEMBL241626 — — 1 6.40
CHEMBL392581 — — 1 6.40
CHEMBL391897 — — 1 6.40
CHEMBL239920 — — 1 6.40
CHEMBL241417 — — 1 6.40
CHEMBL393977 — — 1 6.40
CHEMBL393804 — — 1 6.30
CHEMBL241203 — — 1 6.20
CHEMBL239705 — — 1 6.20
CHEMBL394017 — — 1 6.10
CHEMBL240993 — — 1 6.10
CHEMBL393954 — — 1 6.00
CHEMBL240575 — — 1 6.00
CHEMBL241202 — — 1 6.00
CHEMBL391246 — — 1 5.90
CHEMBL238473 — — 1 5.80
CHEMBL399824 — — 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL394240 — IC50 = 50.12 nM 7.30
CHEMBL391255 — IC50 = 79.43 nM 7.10
CHEMBL392580 — IC50 = 100.0 nM 7.00
CHEMBL391054 — IC50 = 158.49 nM 6.80
CHEMBL393803 — IC50 = 199.53 nM 6.70
CHEMBL240781 — IC50 = 199.53 nM 6.70
CHEMBL391059 — IC50 = 199.53 nM 6.70
CHEMBL241005 — IC50 = 199.53 nM 6.70
CHEMBL392764 — IC50 = 251.19 nM 6.60
CHEMBL238692 — IC50 = 251.19 nM 6.60
CHEMBL238691 — IC50 = 251.19 nM 6.60
CHEMBL241009 — IC50 = 316.23 nM 6.50
CHEMBL393217 — IC50 = 316.23 nM 6.50
CHEMBL241417 — IC50 = 398.11 nM 6.40
CHEMBL392581 — IC50 = 398.11 nM 6.40
CHEMBL391897 — IC50 = 398.11 nM 6.40
CHEMBL239920 — IC50 = 398.11 nM 6.40
CHEMBL241626 — IC50 = 398.11 nM 6.40
CHEMBL393977 — IC50 = 398.11 nM 6.40
CHEMBL393804 — IC50 = 501.19 nM 6.30
CHEMBL241203 — IC50 = 630.96 nM 6.20
CHEMBL239705 — IC50 = 630.96 nM 6.20
CHEMBL394017 — IC50 = 794.33 nM 6.10
CHEMBL240993 — IC50 = 794.33 nM 6.10
CHEMBL241202 — IC50 = 1000.0 nM 6.00
CHEMBL240575 — IC50 = 1000.0 nM 6.00
CHEMBL393954 — IC50 = 1000.0 nM 6.00
CHEMBL391246 — IC50 = 1258.93 nM 5.90
CHEMBL238473 — IC50 = 1584.89 nM 5.80
CHEMBL399824 — IC50 = 1584.89 nM 5.80
CHEMBL240576 — IC50 = 1995.26 nM 5.70
CHEMBL238488 — IC50 = 1995.26 nM 5.70
CHEMBL238478 — IC50 = 1995.26 nM 5.70
CHEMBL238474 — IC50 = 2511.89 nM 5.60
CHEMBL238686 — IC50 = 2511.89 nM 5.60
CHEMBL393764 — IC50 = 2511.89 nM 5.60
CHEMBL240365 — IC50 = 2511.89 nM 5.60
CHEMBL239704 — IC50 = 5011.87 nM 5.30
CHEMBL391245 — IC50 = 6309.57 nM 5.20
CHEMBL238688 — IC50 = 7943.28 nM 5.10
CHEMBL391453 — IC50 = 10000.0 nM 5.00
CHEMBL238896 — IC50 = 12589.25 nM 4.90
CHEMBL393962 — IC50 = 25118.86 nM 4.60
CHEMBL444634 — IC50 = 25118.86 nM 4.60
CHEMBL266714 — IC50 = 31622.78 nM 4.50
CHEMBL238477 — IC50 = 31622.78 nM 4.50
CHEMBL240574 — IC50 = 63095.73 nM 4.20
CHEMBL393406 — Activity - — -
CHEMBL401460 — Activity - — -
CHEMBL442092 — Activity - — -