Assay Detail
Functional
CHEMBL902059
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Antitumor activity in MV522 cells assessed as inhibition of DNA synthesis after 2 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV522 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of amine analogs of irofulven.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.84 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 6.96 |
| CHEMBL437755 | — | — | 1 | 6.33 |
| CHEMBL393438 | — | — | 1 | 6.30 |
| CHEMBL392242 | — | — | 1 | 5.31 |
| CHEMBL235976 | — | — | 1 | 5.10 |
| CHEMBL439562 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL437755 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL393438 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL392242 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL235976 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL439562 | — | IC50 | = | 8900.0 | nM | 5.05 |