Assay Detail
Functional
CHEMBL902060
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Antitumor activity in MV522 cells assessed as cell survival after 48 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV522 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of amine analogs of irofulven.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.36 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 7.16 |
| CHEMBL439562 | — | — | 1 | 6.77 |
| CHEMBL437755 | — | — | 1 | 6.37 |
| CHEMBL393438 | — | — | 1 | 6.07 |
| CHEMBL392242 | — | — | 1 | 5.92 |
| CHEMBL235976 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL439562 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL437755 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL393438 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL392242 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL235976 | — | IC50 | = | 1300.0 | nM | 5.89 |