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Assay Detail

CHEMBL902069

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Antiproliferative activity against human HMEC cells by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HMEC
Confidence 1 — Organism
Curated By Autocuration

Target

HMEC (CHEMBL614734)
Type CELL-LINE
Organism Homo sapiens

Publication

N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.
Vaisburg A, Paquin I, Bernstein N, Frechette S, Gaudette F, Leit S, Moradei O, Raeppel S, Zhou N, Bouchain G, Woo SH, Jin Z, Gillespie J, Wang J, Fournel M, Yan PT, Trachy-Bourget MC, Robert MF, Lu A, Yuk J, Rahil J, Macleod AR, Besterman JM, Li Z, Delorme D.
Bioorg Med Chem Lett (2007) 17 : 6729 -6733
PubMed 17977726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.76 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL396444 1 5.22
CHEMBL398394 1 5.10
CHEMBL238568 1 5.05
CHEMBL240915 1 4.77
CHEMBL241337 1 4.75
CHEMBL400419 1 4.68
CHEMBL238569 1 4.64
CHEMBL241549 1 4.60
CHEMBL392449 1 4.55
CHEMBL401449 1 4.54
CHEMBL239625 1 4.43
CHEMBL241550 1 -
CHEMBL401448 1 -
CHEMBL241551 1 -
CHEMBL241338 1 -
CHEMBL241757 1 -
CHEMBL241129 1 -
CHEMBL400213 1 -
CHEMBL241759 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL396444 IC50 = 6000.0 nM 5.22
CHEMBL398394 IC50 = 8000.0 nM 5.10
CHEMBL238568 IC50 = 9000.0 nM 5.05
CHEMBL240915 IC50 = 17000.0 nM 4.77
CHEMBL241337 IC50 = 18000.0 nM 4.75
CHEMBL400419 IC50 = 21000.0 nM 4.68
CHEMBL238569 IC50 = 23000.0 nM 4.64
CHEMBL241549 IC50 = 25000.0 nM 4.60
CHEMBL392449 IC50 = 28000.0 nM 4.55
CHEMBL401449 IC50 = 29000.0 nM 4.54
CHEMBL239625 IC50 = 37000.0 nM 4.43
CHEMBL241550 IC50 > 25000.0 nM -
CHEMBL401448 IC50 > 25000.0 nM -
CHEMBL241551 IC50 > 25000.0 nM -
CHEMBL241338 IC50 > 42000.0 nM -
CHEMBL241757 IC50 > 50000.0 nM -
CHEMBL241129 IC50 > 50000.0 nM -
CHEMBL400213 IC50 > 50000.0 nM -
CHEMBL241759 IC50 > 50000.0 nM -