Compound Detail
CHEMBL241551
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COc1ccc(Cn2c(=O)n(Cc3ccc(C(=O)Nc4ccccc4N)cc3)c(=O)c3ccccc32)cc1
Basic Information
| ChEMBL ID | CHEMBL241551 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IHYMBMWMBGROQG-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
506.6
MW (Da)
4.10
ALogP
7
HBA
2
HBD
108.3
PSA (Ų)
0.32
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.0
IC50 2 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase 1 CHEMBL325 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| HCT-116 CHEMBL394 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| T-24 CHEMBL614774 | EC50 | 6.0 | 5.76 | 1000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 1 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of human recombinant HDAC1 expressed in insect Sf9 cells | 17977726 |
| HCT-116 | IC50 | = | 800.0 | nM | 6.1 | Antiproliferative activity against human HCT116 cells by MTT assay | 17977726 |
| T-24 | EC50 | = | 1000.0 | nM | 6.0 | Induction of histone H4 acetylation in human T24 cells after 16 hrs by immunoblo... | 17977726 |
| T-24 | EC50 | = | 3000.0 | nM | 5.52 | Induction of p21WAF1/Cip1 expression in human T24 cells assessed as tubulin leve... | 17977726 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17977726 | 10.1016/j.bmcl.2007.10.050 | HCT-116 | 3 |
| 17977726 | 10.1016/j.bmcl.2007.10.050 | T-24 | 2 |
| 17977726 | 10.1016/j.bmcl.2007.10.050 | Histone deacetylase 1 | 1 |
| 17977726 | 10.1016/j.bmcl.2007.10.050 | HMEC | 1 |
Data from ChEMBL 36 via Core Engine