Assay Detail
Binding
CHEMBL902103
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Inhibition of human recombinant GST-Tie2 by HTRF method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.92 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241682 | — | — | 1 | 7.77 |
| CHEMBL241681 | — | — | 1 | 7.34 |
| CHEMBL391692 | — | — | 1 | 5.66 |
| CHEMBL241517 | GW856804X | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241682 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL241681 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL391692 | — | IC50 | = | 2188.0 | nM | 5.66 |
| CHEMBL241517 | GW856804X | IC50 | > | 20000.0 | nM | - |