Assay Detail
Binding
CHEMBL902114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine TACE
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3332) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.09 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395880 | — | — | 1 | 8.70 |
| CHEMBL247966 | — | — | 1 | 8.30 |
| CHEMBL241051 | — | — | 1 | 8.15 |
| CHEMBL240855 | — | — | 1 | 8.00 |
| CHEMBL427861 | — | — | 1 | 7.89 |
| CHEMBL395878 | — | — | 1 | 7.89 |
| CHEMBL240854 | — | — | 1 | 7.85 |
| CHEMBL240464 | — | — | 1 | 7.80 |
| CHEMBL440048 | — | — | 1 | 7.75 |
| CHEMBL240653 | — | — | 1 | 7.72 |
| CHEMBL247967 | — | — | 1 | 7.62 |
| CHEMBL241048 | — | — | 1 | 7.58 |
| CHEMBL240465 | — | — | 1 | 7.54 |
| CHEMBL391288 | — | — | 1 | 7.54 |
| CHEMBL395877 | — | — | 1 | 7.54 |
| CHEMBL240648 | — | — | 1 | 7.51 |
| CHEMBL429112 | — | — | 1 | 7.44 |
| CHEMBL248172 | — | — | 1 | 7.36 |
| CHEMBL240652 | — | — | 1 | 7.33 |
| CHEMBL438125 | — | — | 1 | 7.28 |
| CHEMBL240654 | — | — | 1 | 7.26 |
| CHEMBL248173 | — | — | 1 | 7.26 |
| CHEMBL428212 | — | — | 1 | 7.24 |
| CHEMBL240852 | — | — | 1 | 7.24 |
| CHEMBL393944 | — | — | 1 | 7.21 |
| CHEMBL392867 | — | — | 1 | 6.96 |
| CHEMBL391376 | — | — | 1 | 6.89 |
| CHEMBL442423 | — | — | 1 | 6.86 |
| CHEMBL241047 | — | — | 1 | 6.10 |
| CHEMBL193316 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395880 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL247966 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL241051 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL240855 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL427861 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL395878 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL240854 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL240464 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL440048 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL240653 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL247967 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL241048 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL240465 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL391288 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL395877 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL240648 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL429112 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL248172 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL240652 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL438125 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL248173 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL240654 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL428212 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL240852 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL393944 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL392867 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL391376 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL442423 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL241047 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL193316 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL240651 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL240849 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL240463 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL240851 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL392062 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL240850 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL241049 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL391851 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL393723 | — | IC50 | > | 100000.0 | nM | - |