Assay Detail
Functional
CHEMBL902173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at progesterone receptor expressed in T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.24 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247902 | — | — | 1 | 8.30 |
| CHEMBL247053 | — | — | 1 | 8.09 |
| CHEMBL396908 | — | — | 1 | 8.08 |
| CHEMBL428210 | — | — | 1 | 8.05 |
| CHEMBL239792 | — | — | 1 | 8.04 |
| CHEMBL248101 | — | — | 1 | 7.88 |
| CHEMBL247054 | — | — | 1 | 7.84 |
| CHEMBL136721 | — | — | 1 | 7.82 |
| CHEMBL343306 | — | — | 1 | 7.64 |
| CHEMBL247295 | — | — | 1 | 7.56 |
| CHEMBL394306 | — | — | 1 | 7.53 |
| CHEMBL391361 | — | — | 1 | 7.52 |
| CHEMBL398801 | — | — | 1 | 7.49 |
| CHEMBL396093 | — | — | 1 | 7.43 |
| CHEMBL247499 | — | — | 1 | 7.38 |
| CHEMBL246885 | — | — | 1 | 7.26 |
| CHEMBL246884 | — | — | 1 | 7.25 |
| CHEMBL241732 | — | — | 1 | 7.18 |
| CHEMBL241733 | — | — | 1 | 7.14 |
| CHEMBL392848 | — | — | 1 | 7.00 |
| CHEMBL393641 | — | — | 1 | 6.69 |
| CHEMBL393642 | — | — | 1 | 6.00 |
| CHEMBL246886 | — | — | 1 | 6.00 |
| CHEMBL392704 | — | — | 1 | 6.00 |
| CHEMBL247090 | — | — | 1 | 5.52 |
| CHEMBL247089 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247902 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL247053 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL396908 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL428210 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL239792 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL248101 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL247054 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL136721 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL343306 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL247295 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL394306 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL391361 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL398801 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL396093 | — | IC50 | = | 37.1 | nM | 7.43 |
| CHEMBL247499 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL246885 | — | IC50 | = | 54.4 | nM | 7.26 |
| CHEMBL246884 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL241732 | — | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL241733 | — | IC50 | = | 71.8 | nM | 7.14 |
| CHEMBL392848 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL393641 | — | IC50 | = | 205.8 | nM | 6.69 |
| CHEMBL393642 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL246886 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL392704 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL247090 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL247089 | — | IC50 | = | 3000.0 | nM | 5.52 |