Assay Detail
Binding
CHEMBL902272
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Inhibition of human DPP8
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.57 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | 3.0 | 1 | 7.77 |
| CHEMBL398076 | — | — | 1 | 5.37 |
| CHEMBL397057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL398076 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL397057 | — | IC50 | > | 20000.0 | nM | - |