Compound Detail
CHEMBL398076
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Basic Information
| ChEMBL ID | CHEMBL398076 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JAXKDVVQQUKJKR-YUMQZZPRSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
231.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 9.32 | 9.32 | 0.5 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 5.37 | 5.37 | 4300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 2 | IC50 | = | 0.48 | nM | 9.32 | Inhibition of human DPP2 | 17055271 |
| Dipeptidyl peptidase 9 | IC50 | = | 800.0 | nM | 6.1 | Inhibition of human DPP9 | 17055271 |
| Dipeptidyl peptidase 8 | IC50 | = | 4300.0 | nM | 5.37 | Inhibition of human DPP8 | 17055271 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17055271 | 10.1016/j.bmcl.2006.10.012 | Dipeptidyl peptidase 2 | 2 |
| 17055271 | 10.1016/j.bmcl.2006.10.012 | Unchecked | 1 |
| 17055271 | 10.1016/j.bmcl.2006.10.012 | Dipeptidyl peptidase 4 | 1 |
| 17055271 | 10.1016/j.bmcl.2006.10.012 | Prolyl endopeptidase FAP | 1 |
| 17055271 | 10.1016/j.bmcl.2006.10.012 | Dipeptidyl peptidase 8 | 1 |
| 17055271 | 10.1016/j.bmcl.2006.10.012 | Dipeptidyl peptidase 9 | 1 |
| 17055271 | 10.1016/j.bmcl.2006.10.012 | Prolyl endopeptidase | 1 |
Data from ChEMBL 36 via Core Engine