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Assay Detail

CHEMBL902313

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK3
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Mitogen-activated protein kinase 10 (CHEMBL2637)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.
Liu G, Zhao H, Liu B, Xin Z, Liu M, Serby MD, Lubbers NL, Widomski DL, Polakowski JS, Beno DW, Trevillyan JM, Sham HL.
Bioorg Med Chem Lett (2007) 17 : 495 -500
PubMed 17055723 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.70 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL437747 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL437747 IC50 = 2.0 nM 8.70