Assay Detail
Binding
CHEMBL902336
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Inhibition of mushroom tyrosinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.30 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248499 | — | — | 1 | 7.47 |
| CHEMBL392209 | — | — | 1 | 6.31 |
| CHEMBL246045 | — | — | 1 | 5.53 |
| CHEMBL195217 | — | — | 1 | 5.19 |
| CHEMBL197892 | — | — | 1 | 4.78 |
| CHEMBL537 | HYDROQUINONE | 4.0 | 1 | 4.47 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.42 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248499 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL392209 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL246045 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL195217 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL197892 | — | IC50 | = | 16520.0 | nM | 4.78 |
| CHEMBL537 | HYDROQUINONE | IC50 | = | 33480.0 | nM | 4.47 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 38240.0 | nM | 4.42 |
| CHEMBL165 | RESVERATROL | IC50 | = | 55610.0 | nM | 4.25 |