Assay Detail
Functional
CHEMBL902403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.06 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225155 | — | — | 1 | 9.04 |
| CHEMBL190006 | — | — | 1 | 8.54 |
| CHEMBL247699 | — | — | 1 | 8.24 |
| CHEMBL393055 | — | — | 1 | 7.99 |
| CHEMBL247901 | — | — | 1 | 7.67 |
| CHEMBL247698 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225155 | — | EC50 | = | 0.91 | nM | 9.04 |
| CHEMBL190006 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL247699 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL393055 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL247901 | — | EC50 | = | 21.3 | nM | 7.67 |
| CHEMBL247698 | — | EC50 | = | 133.8 | nM | 6.87 |